Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-06-30 , DOI: 10.2174/1389557520666201214102151 Jaya Dwivedi 1 , Neetu Yaduvanshi 1 , Shruti Shukla 1 , Sonika Jain 1
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Since 1887, phenoxazine derivatives have attracted the attention of chemists due to their versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, anti-depressant, analgesic and many other drug resistance reversal activities. This review covers a detailed overview of the pharmacological application of phenoxazine nucleus, its chemistry and reactivity, and also illustrating the incorporation of different groups at different positions enhancing its biological application, besides some synthetic procedures.
中文翻译：
吩恶嗪衍生物的药用和生物学意义
自 1887 年以来，吩恶嗪衍生物因其在工业和药理学上的多功能用途而引起了化学家的注意。文献发现吩恶嗪衍生物具有多种药理活性，如抗肿瘤、抗癌、抗真菌、抗菌、抗炎、抗糖尿病、抗病毒、抗疟疾、抗抑郁、镇痛和许多其他耐药逆转活性。本综述详细概述了吩恶嗪核的药理应用、其化学和反应性，并说明了在不同位置加入不同基团以增强其生物学应用，以及一些合成程序。
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