Capillary electrophoresis (CE) is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures, analysis of biomolecules, and characterization of biopharmaceuticals. Currently, CE is the method of choice for the analysis of foodstuffs and the determination of adulterants. This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques. It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade. The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples. This review will help scientists, fellow researchers, and students to understand the applications of CE techniques in the impurity profiling of drugs.

毛细管电泳 (CE) 广泛用于结构中含有立体化学中心的药物的杂质分析、生物分子的分析和生物药物的表征。目前，CE 是食品分析和掺杂物测定的首选方法。本文讨论了 CE 的一般理论和仪器以及各种 CE 技术的分类。它还概述了过去十年中不同 CE 技术在药物杂质分析中的应用研究。该综述简要介绍了 CE 和液相色谱方法之间的比较，并以药物化合物为例强调了 CE 的优势。这篇综述将帮助科学家、研究人员、