Abstract

A pair of new lignans [(+)- 1 and (-)- 1] and three new compounds (2-4), together with a known compound 5, were isolated from the fruits of Xanthium italicum Moretti. The structures of these compounds were determined on the basis of spectroscopic analysis, particularly HR-ESI-MS and 1 D and 2 D NMR. Compounds 2 and 3 showed antinociceptive effects in an acetic acid-induced writhing test in mice with the writhe inhibition rates of 80.50% and 67.89% at the dose of 20 mg/kg, respectively.

中文翻译：

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来自意大利苍耳莫雷蒂果实的新木脂素和二萜糖苷

摘要

一对新的木脂素[(+)- 1和(-)- 1 ] 和三种新的化合物( 2-4 ) 以及已知的化合物5从意大利苍耳子的果实中分离得到。这些化合物的结构是在光谱分析的基础上确定的，特别是 HR-ESI-MS 和 1 D 和 2 D NMR。化合物2和3在醋酸诱导的小鼠扭体试验中表现出镇痛作用，20 mg/kg剂量下的扭体抑制率分别为80.50%和67.89%。