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Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions?
Structure ( IF 4.4 ) Pub Date : 2021-07-01 , DOI: 10.1016/j.str.2021.06.011
Juan J Ramirez 1 , Dhanesh Sivadasan Bindu 2 , Cagla Eroglu 3
Affiliation  

Astrocyte-secreted Hevin induces synapse formation by bridging the trans-synaptic organizers, neuroligins and neurexins. In this issue of Structure, Fan et al. (2021) elucidate the structural basis of Hevin’s interaction with these molecules and reveal the competitive interplay between Hevin, SPARC, and MDGAs.



中文翻译:

构建和破坏突触桥:Hevin/Sparcl1、SPARC 和 MDGAs 如何修改跨突触神经蛋白-神经寡糖相互作用?

星形胶质细胞分泌的 Hevin 通过桥接跨突触组织者、neuroligin 和 neurexins 来诱导突触形成。在本期Structure 中,Fan 等人。(2021) 阐明了 Hevin 与这些分子相互作用的结构基础,并揭示了 Hevin、SPARC 和 MDGA 之间的竞争性相互作用。

更新日期:2021-07-01
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