Chronic glomerular hypertension is associated with glomerular injury and sclerosis; however, the mechanism by which increases in pressure damage glomerular podocytes remains unclear. We tested the hypothesis that increases in glomerular pressure may deleteriously affect podocyte structural integrity by increasing the strain of the glomerular capillary walls, and that glomerular capillary wall strain may play a significant role in the perpetuation of glomerular injury in disease states that are associated with glomerular hypertension.

中文翻译：

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5/6肾切除大鼠肾小球毛细血管壁应变增加的模拟

慢性肾小球高血压与肾小球损伤和硬化有关；然而，压力损伤肾小球足细胞增加的机制仍不清楚。我们验证了肾小球压力增加可能通过增加肾小球毛细血管壁的应变对足细胞结构完整性产生有害影响的假设，并且肾小球毛细血管壁应变可能在与肾小球相关的疾病状态下肾小球损伤的持续存在中起重要作用。高血压。