The changes in functional brain connectivity induced by treatment with analgesics are poorly investigated. Unfortunately, results from clinical studies investigating treatments in patients with pain are often confounded by co-medication and comorbidity. Thalamus is central in sensory processing, and we hypothesized that functional connectivity between thalamus and other brain areas in healthy volunteers was different in treatment with oxycodone, representing a pure opioid, compared to treatment with tapentadol, which has a dual effect on the opioidergic and adrenergic systems.

中文翻译：

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他喷他多和羟考酮影响静息状态功能性大脑连接：一项随机、安慰剂对照试验

镇痛药治疗引起的功能性大脑连接的变化研究很少。不幸的是，研究疼痛患者治疗的临床研究结果常常被联合用药和合并症混淆。丘脑是感觉处理的核心，我们假设健康志愿者的丘脑和其他大脑区域之间的功能连接在用代表纯阿片类药物的羟考酮治疗时与用他喷他多治疗不同，后者对阿片能和肾上腺素能有双重作用系统。