Abstract

Background

Erectile dysfunction (ED) is an early form of atherosclerosis and subclinical myocardial dysfunction. Epicardial fat tissue (EFT) is associated with impaired left ventricular (LV) function, even in the absence of cardiovascular disease. The aim of this study was to investigate the association between EFT and LV systolic function in patients with erectile ED by speckle tracking echocardiography (2D-STE) method.

Methods

A total of 129 consecutive patients with ED were compared with 145 age- and sex-matched control subjects. ED was evaluated using the International Index of Erectile Function questionnaire. Thickness of EFT was measured by TTE. Global LV longitudinal strain (LV-GLS) and global LV circumferential strain (LV-GCS) were measured by 2D-STE method.

Results

The EFT thickness was significantly higher in the patients with ED (p <.01). LV-GLS and LV-GCS were revealed to be more deterioration in the ED group compared to controls (−18.2 ± 2.7 vs. (−21.1 ± 3.9, p<.001; −19.5 ± 4.1 vs. −21.9 ± 3.9, p<.001, respectively). It has been shown that EFT thickness is an independent predictor of LV dysfunction.

Conclusions

These results indicate that EFT thickness is associated with subclinical LV systolic dysfunction in patients with ED.

中文翻译：

---

心外膜脂肪组织可预测勃起功能障碍患者的亚临床左心室功能障碍

摘要

背景

勃起功能障碍 (ED) 是动脉粥样硬化和亚临床心肌功能障碍的早期形式。即使没有心血管疾病，心外膜脂肪组织 (EFT) 也与受损的左心室 (LV) 功能有关。本研究的目的是通过斑点跟踪超声心动图 (2D-STE) 方法调查勃起性 ED 患者 EFT 与左室收缩功能之间的关联。

方法

共有 129 名连续的 ED 患者与 145 名年龄和性别匹配的对照受试者进行了比较。ED 使用国际勃起功能指数问卷进行评估。EFT 的厚度是通过 TTE 测量的。全球 LV 纵向应变 (LV-GLS) 和全球 LV 周向应变 (LV-GCS) 通过 2D-STE 方法测量。

结果

ED 患者的 EFT 厚度显着更高（p <.01）。与对照组相比，ED 组的 LV-GLS 和 LV-GCS 恶化程度更高（-18.2 ± 2.7 vs. (-21.1 ± 3.9, p <.001; -19.5 ± 4.1 vs. -21.9 ± 3.9, p <.001，分别). 已经表明，EFT 厚度是 LV 功能障碍的独立预测因素。

结论

这些结果表明 EFT 厚度与 ED 患者的亚临床 LV 收缩功能障碍有关。