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Trace element imbalances in blood serum of Alzheimer’s disease patients
Spectroscopy Letters ( IF 1.7 ) Pub Date : 2021-06-30 , DOI: 10.1080/00387010.2021.1941124
R. D. Lavanya 1 , B. Seetharami Reddy 2 , Sheik Abdul Sattar 3 , A. D. P. Rao 2
Affiliation  

Abstract

Trace element concentration of blood serum samples of patients afflicted with Alzheimer’s disease and controls were determined using inductively coupled plasma-mass spectrometry. 22 elements starting from low atomic number element lithium to high atomic number element lead were covered under this study. The concentration of lithium and vanadium were measured for the first time. The concentration levels of lithium, aluminum, vanadium, chromium, manganese, iron, cobalt, nickel, zinc, arsenic, selenium, silver, cadmium, cesium, mercury, and lead are found to be higher and the concentration levels of gallium, rubidium, and barium to be lower in the samples of the Alzheimer’s disease afflicted patients compared to controls. The difference in the concentration levels of beryllium, copper, and strontium between the specimens of Alzheimer's disease patients and controls is statistically insignificant. An attempt is made to correlate the trace element imbalance, where observed, with the etiology and pathogenesis of Alzheimer’s disease.



中文翻译:

阿尔茨海默病患者血清微量元素失衡

摘要

使用电感耦合等离子体质谱法测定患有阿尔茨海默病的患者和对照的血清样品的微量元素浓度。这项研究涵盖了从低原子序数元素锂到高原子序数元素铅的 22 种元素。首次测量了锂和钒的浓度。发现锂、铝、钒、铬、锰、铁、钴、镍、锌、砷、硒、银、镉、铯、汞和铅的浓度水平较高,镓、铷、与对照组相比,阿尔茨海默病患者样本中的钡含量较低。阿尔茨海默病标本之间铍、铜和锶的浓度水平差异 s 疾病患者和控件在统计上是微不足道的。试图将观察到的微量元素失衡与阿尔茨海默病的病因和发病机制联系起来。

更新日期:2021-07-22
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