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Characteristics and management of hydrocephalus in adult patients with cerebellar glioblastoma: lessons from a French nationwide series of 118 cases
Neurosurgical Review ( IF 2.8 ) Pub Date : 2021-07-01 , DOI: 10.1007/s10143-021-01578-2
Thiébaud Picart 1, 2, 3 , Chloé Dumot 1, 2, 4 , David Meyronet 2, 3, 5 , Johan Pallud 6, 7, 8 , Philippe Metellus 9, 10 , Sonia Zouaoui 11, 12 , François Ducray 2, 3, 13 , Isabelle Pelissou-Guyotat 1 , Moncef Berhouma 1, 2, 14 , Luc Bauchet 11, 12, 15 , Jacques Guyotat 1 , ,
Affiliation  

The characteristics of hydrocephalus associated with cerebellar glioblastoma (cGB) remain poorly known. The objectives were to describe the occurence of hydrocephalus in a French nationwide series of adult patients with cGB, to identify the characteristics associated with hydrocephalus and to analyze the outcomes associated with the different surgical strategies, in order to propose practical guidelines. Consecutive cases of adult cGB patients prospectively recorded into the French Brain Tumor Database between 2003 and 2017 were screened. Diagnosis was confirmed by a centralized neuropathological review. Among 118 patients with cGB (mean age 55.9 years), 49 patients (41.5%) presented with pre-operative hydrocephalus. Thirteen patients (11.0%) developed acute (n=7) or delayed (n=6) hydrocephalus postoperatively. Compared to patients without hydrocephalus at admission, patients with hydrocephalus were younger (52.0 years vs 58.6 years, p=0.03) and underwent more frequently tumor resection (93.9% vs 73.9%, p=0.006). A total of 40 cerebrospinal-fluid diversion procedures were performed, including 18 endoscopic third ventriculostomies, 12 ventriculoperitoneal shunts and 10 external ventricular drains. The different cerebrospinal-fluid diversion options had comparable functional results and complication rates. Among the 89 patients surgically managed for cGB without prior cerebrospinal-fluid diversion, 7 (7.9%) were long-term shunt-dependant. Hydrocephalus is frequent in patients with cGB and has to be carefully managed in order not to interfere with adjuvant oncological treatments. In case of symptomatic hydrocephalus, a cerebrospinal-fluid diversion is mandatory, especially if surgical resection is not feasible. In case of asymptomatic hydrocephalus, a cerebrospinal-fluid diversion has to be discussed only if surgical resection is not feasible.



中文翻译:

成人小脑胶质母细胞瘤患者脑积水的特征和治疗:来自法国全国 118 例病例系列的经验教训

与小脑胶质母细胞瘤 (cGB) 相关的脑积水的特征仍然鲜为人知。目的是描述法国全国范围内的 cGB 成年患者脑积水的发生情况,确定与脑积水相关的特征并分析与不同手术策略相关的结果,以提出实用的指南。筛选了 2003 年至 2017 年间前瞻性记录到法国脑肿瘤数据库中的成年 cGB 患者的连续病例。诊断通过集中的神经病理学检查得到证实。在 118 名 cGB 患者(平均年龄 55.9 岁)中,49 名患者(41.5%)出现术前脑积水。13 名患者 (11.0%) 发展为急性 ( n = 7) 或延迟 ( n=6) 术后脑积水。与入院时没有脑积水的患者相比,脑积水患者更年轻(52.0 岁 vs 58.6 岁,p= 0.03)并且接受肿瘤切除的频率更高(93.9% vs 73.9%,p=0.006)。共实施脑脊液分流术40例,其中内镜下第三脑室造口术18例,脑室腹腔分流术12例,脑室外引流术10例。不同的脑脊液分流方案具有相当的功能结果和并发症发生率。在没有脑脊液分流的情况下接受 cGB 手术治疗的 89 名患者中,7 名(7.9%)长期依赖分流术。脑积水在 cGB 患者中很常见,必须小心管理,以免干扰辅助肿瘤治疗。对于有症状的脑积水,必须进行脑脊液分流,尤其是在手术切除不可行的情况下。在无症状脑积水的情况下,只有在手术切除不可行时才需要讨论脑脊液分流。

更新日期:2021-07-01
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