Purpose: Adrenocorticotropic hormone (ACTH)-dependent Cushing's disease accounts for 75% cases of the endogenous Cushing's syndrome. The size of lesion is usually very small, which results in false-negative magnetic resonance imaging (MRI) even after biochemical confirmation of the disease. Corticotrophin-releasing hormone (CRH) the key controller of hypothalamus–pituitary–-adrenal axis binds to CRH receptor R1 and R2. CRH R1 is overexpressed in pituitary adenomas. The present study aims to target these overexpressed receptors with ⁶⁸Ga-DOTA-CRH for noninvasive imaging of ACTH-dependent pituitary adenomas.

中文翻译：

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开发 68Ga DOTA-CRH 用于 ACTH 依赖性库欣病的 PET/CT 成像：初步研究

目的：促肾上腺皮质激素 (ACTH) 依赖性库欣病占内源性库欣综合征病例的 75%。病变的大小通常非常小，即使在疾病生化确认后，也会导致磁共振成像 (MRI) 出现假阴性。促肾上腺皮质激素释放激素 (CRH) 是下丘脑-垂体-肾上腺轴的关键控制器，与 CRH 受体 R1 和 R2 结合。CRH R1 在垂体腺瘤中过度表达。本研究旨在以⁶⁸ Ga-DOTA-CRH 靶向这些过表达受体，用于 ACTH 依赖性垂体腺瘤的无创成像。