Prenatal, perinatal, and postnatal factors have been shown to shape neurobiological functioning and alter the risk for mental disorders later in life. The gut microbiome is established early in life, and interacts with the brain via the brain-immune-gut axis. However, little is known about how the microbiome relates to early-life cognitive functioning in children. The present study, where the fecal microbiome of 380 children was characterized using 16s rDNA and metagenomic sequencing aimed to investigate the association between the microbiota and cognitive functioning of children at the age of 45 months measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III).

中文翻译：

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微生物组谱与 45 个月大儿童的认知功能有关

产前、围产期和产后因素已被证明会影响神经生物学功能并改变日后发生精神障碍的风险。肠道微生物组在生命早期建立，并通过大脑-免疫-肠道轴与大脑相互作用。然而，人们对微生物组与儿童早期认知功能的关系知之甚少。本研究使用 16s rDNA 和宏基因组测序对 380 名儿童的粪便微生物组进行了表征，旨在调查使用 Wechsler 学龄前和初级智力量表 (WPPSI) 测量的 45 个月大儿童的微生物组与认知功能之间的关联。 -III)。