To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (n_total = 75,666, n_women = 47,700, n_men = 27,966; ages 18–85 years old, mean (M)_Age = 46.54, standard deviation (SD)_Age = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (n_total = 158,249 n_women = 89,333 n_men = 68,916; ages 40–70 years old, M_Age = 55.81, SD_Age = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (n_total = 39,795, n_women = 29,640, n_men = 10,155; ages 40–70 years old, M_Age = 56.59, SD_Age = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer’s disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.

为了确定影响与年龄相关的认知能力下降和疾病的潜在因素，我们创建了 MindCrowd。MindCrowd 是一种基于网络的横截面评估，用于评估简单视觉 (sv) 反应时间 (RT) 和配对联想学习 (PAL)。svRT 和 PAL 结果与 22 个调查问题相结合。svRT 分析显示，教育和中风是处理速度和记忆力变化的潜在修饰符，从年轻到年长（n_总数 = 75,666，n_女性 = 47,700，n_男性 = 27,966；年龄 18-85 岁，平均 ( M )_年龄 = 46.54，标准偏差(SD)_年龄 = 18.40）。为了补充这项工作，我们评估了英国生物银行的复杂视觉识别反应时间 (cvrRT)（n_总数 = 158,249 n_女性 = 89,333 n_男性 = 68,916；年龄 40-70 岁，M_年龄 = 55.81，SD_年龄 = 7.72） . UK Biobank 和 MindCrowd 之间的相似性是使用 MindCrowd (UKBb MindCrowd) 的一个子集评估的，该子集被选择以反映英国生物银行的人口统计数据（n_总数 = 39,795，n_女性 = 29,640，n_男性 = 10,155；年龄 40-70 岁，M_年龄 = 56.59，SD_年龄 = 8.16）。使用相同的线性模型 (LM) 来评估两个队列。分析揭示了 MindCrowd 和 UK Biobank 在大多数结果上的相似之处。来自英国生物银行的不同发现包括：(1) 一级阿尔茨海默病 (FHAD) 家族史与较长的 cvrRT 相关。(2) 与所有受教育水平的女性相比，受教育程度最低的男性与更长的 cvrRTs 相关。来自 UKBb MindCrowd 的不同发现包括更多的教育与更短的 svRTs 相关，以及从年轻到年长的吸烟史与更长的 svRTs。