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Delays in presentation and mortality among Black patients with mechanical thrombectomy after large-vessel stroke at a US hospital
Neurosurgical Focus ( IF 3.3 ) Pub Date : 2021-07-01 , DOI: 10.3171/2021.4.focus2182
Joshua S. Catapano 1 , Kavelin Rumalla 1 , Visish M. Srinivasan 1 , Candice L. Nguyen 1 , Dara S. Farhadi 1 , Brandon Ngo 1 , Caleb Rutledge 1 , Redi Rahmani 1 , Jacob F. Baranoski 1 , Tyler S. Cole 1 , Ashutosh P. Jadhav 1 , Andrew F. Ducruet 1 , Felipe C. Albuquerque 1
Affiliation  

OBJECTIVE

The incidence and severity of stroke are disproportionately greater among Black patients. In this study, the authors sought to examine clinical outcomes among Black versus White patients after mechanical thrombectomy for stroke at a single US institution.

METHODS

All patients who underwent mechanical thrombectomy at a single center from January 1, 2014, through March 31, 2020, were retrospectively analyzed. Patients were grouped based on race, and demographic characteristics, preexisting conditions, clinical presentation, treatment, and stroke outcomes were compared. The association of race with mortality was analyzed in multivariable logistic regression analysis adjusted for potential confounders.

RESULTS

In total, 401 patients (233 males) with a reported race of Black (n = 28) or White (n = 373) underwent mechanical thrombectomy during the study period. Tobacco use was more prevalent among Black patients (43% vs 24%, p = 0.04), but there were no significant differences between the groups with respect to insurance, coronary artery disease, diabetes, illicit drug use, hypertension, or hyperlipidemia. The mean time from stroke onset to hospital presentation was significantly greater among Black patients (604.6 vs 333.4 minutes) (p = 0.007). There were no differences in fluoroscopy time, procedural success (Thrombolysis in Cerebral Infarction grade 2b or 3), hospital length of stay, or prevalence of hemicraniectomy. In multivariable analysis, Black race was strongly associated with higher mortality (32.1% vs 14.5%, p = 0.01). The disparity in mortality rates resolved after adjusting for the average time from stroke onset to presentation (p = 0.14).

CONCLUSIONS

Black race was associated with an increased risk of death after mechanical thrombectomy for stroke. The increased risk may be associated with access-related factors, including delayed presentation to stroke centers.



中文翻译:

美国医院大血管卒中后机械取栓黑人患者就诊和死亡率的延迟

客观的

黑人患者中风的发生率和严重程度不成比例地更高。在这项研究中,作者试图检查在美国一家机构进行机械取栓治疗卒中后黑人与白人患者的临床结果。

方法

回顾性分析了 2014 年 1 月 1 日至 2020 年 3 月 31 日期间在单中心接受机械取栓的所有患者。患者根据种族进行分组,并比较人口统计学特征、既往状况、临床表现、治疗和卒中结果。在调整了潜在混杂因素的多变量逻辑回归分析中分析了种族与死亡率的关联。

结果

在研究期间,总共有 401 名报告为黑人(n = 28)或白人(n = 373)的患者(233 名男性)接受了机械血栓切除术。烟草使用在黑人患者中更为普遍(43% 对 24%,p = 0.04),但两组之间在保险、冠状动脉疾病、糖尿病、非法药物使用、高血压或高脂血症方面没有显着差异。黑人患者从中风发作到住院的平均时间明显更长(604.6 分钟 vs 333.4 分钟)(p = 0.007)。透视时间、手术成功率(脑梗死溶栓 2b 或 3 级)、住院时间或偏侧颅骨切除术的发生率没有差异。在多变量分析中,黑人与较高的死亡率密切相关(32.1% 对 14.5%,p = 0.01)。

结论

黑人种族与卒中机械取栓后死亡风险增加有关。风险增加可能与访问相关因素有关,包括延迟到卒中中心就诊。

更新日期:2021-07-01
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