In 2021, COVID-19 has been widely spread worldwide. Few studies focused on infection risk in the different confined spaces on university campuses. However, obtaining the quanta value of SARS-CoV-2 using the conventional method is not identical. Therefore, in our study, the estimation method of the quanta value was improved via statistically analyzing the viral load of the infectors and fitting the droplet number concentration of different particle sizes. Moreover, the infection risk and efficacy of typical engineering control measures in confined spaces such as dormitories, classrooms, gyms, libraries, and refectories were evaluated using the improved Wells-Riley equation. The results demonstrated that: (1) the quanta value range of SARS-CoV-2 was 20.49 ∼ 454.87 quanta/h, which was confirmed by the existing literature; (2) the infection risk in dormitories and classrooms was 100% (exposure time was eight hours) and 5% (exposure time was 1.5 h), respectively, while basic reproduction numbers were both 2.8; (3) The combined control measures mainly based on engineering measures such as ventilation, high efficiency particle air (HEPA) filter, ultraviolet germicidal irradiation (UVGI), partially based on surgical masks were recommended. The findings could provide suggestions for universities to scientifically formulate intervention measures and self-protection means for students.

2021年，COVID-19已在全球广泛传播。很少有研究关注大学校园不同密闭空间中的感染风险。但是，使用常规方法获得 SARS-CoV-2 的量子值并不相同。因此，在我们的研究中，通过统计分析感染者的病毒载量并拟合不同粒径的液滴数浓度，改进了量子值的估计方法。此外，使用改进的 Wells-Riley 方程评估了宿舍、教室、体育馆、图书馆和食堂等密闭空间中典型工程控制措施的感染风险和有效性。结果表明：（1）SARS-CoV-2的量子值范围为20.49 ∼ 454.87 quanta/h，已有文献证实；（2）宿舍和教室感染风险分别为100%（暴露时间8小时）和5%（暴露时间1.5小时），基本繁殖数均为2.8；(3) 推荐了以通风、高效粒子空气（HEPA）过滤器、紫外线杀菌（UVGI）等工程措施为主，部分以外科口罩为主的综合控制措施。研究结果可为高校科学制定学生干预措施和自我保护手段提供建议。推荐使用高效粒子空气 (HEPA) 过滤器、紫外线杀菌照射 (UVGI)，部分基于外科口罩。研究结果可为高校科学制定学生干预措施和自我保护手段提供建议。推荐使用高效粒子空气 (HEPA) 过滤器、紫外线杀菌照射 (UVGI)，部分基于外科口罩。研究结果可为高校科学制定学生干预措施和自我保护手段提供建议。