On the track of MDSCs during acute sepsis and in long-term sepsis survivors

Myeloid-derived suppressor cells (MDSCs) are known to be involved in the progression of sepsis inmice. However, due to the lack of a standardised approaches, it has been challenging to translate these observations to patients.

In this issue, De Zuani et al. used a comprehensive flow cytometry panel to follow MDSC dynamics in the development of sepsis and in sepsis survivors. Taking advantage of manual gating and unsupervised metaclustering algorithms, the authors showed that monocytic and polymorphonuclear MDSCs are expanded during the initial stages of the pathology. Furthermore, compared to age-matched healthy donors, patients who survived sepsis showed an accumulation of polymorphonuclear MDSCs which persisted many months after the recovery from sepsis.

This study suggests that MDSCs might play a role in the long-term immunosuppression observed in sepsis survivors and could, thus, represent a valuable therapeutical target to improve the quality of life of these frail patients.

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202049141

中文翻译：

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期刊综述

在急性脓毒症和长期脓毒症幸存者中追踪 MDSCs

已知髓源性抑制细胞 (MDSC) 参与败血症小鼠的进展。然而，由于缺乏标准化的方法，将这些观察结果转化为患者具有挑战性。

在这个问题上，De Zuani 等人。使用全面的流式细胞仪面板来跟踪 MDSC 在败血症发展和败血症幸存者中的动态。利用手动门控和无监督元聚类算法，作者表明单核细胞和多形核 MDSCs 在病理学的初始阶段被扩大。此外，与年龄匹配的健康供体相比，败血症幸存的患者表现出多形核 MDSC 的积累，并在败血症康复后持续数月。

这项研究表明，MDSCs 可能在脓毒症幸存者中观察到的长期免疫抑制中发挥作用，因此可能是改善这些虚弱患者生活质量的有价值的治疗靶点。

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202049141