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Prognostic implications of tumour-infiltrating lymphocytes for recurrence in epithelial ovarian cancer
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-06-30 , DOI: 10.1111/cei.13639 Yuan Wu 1, 2 , Yue Gao 1, 2 , Lingxi Chen 3 , Xin Jin 1, 2 , Pingbo Chen 1, 2 , Qingqing Mo 1, 2
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-06-30 , DOI: 10.1111/cei.13639 Yuan Wu 1, 2 , Yue Gao 1, 2 , Lingxi Chen 3 , Xin Jin 1, 2 , Pingbo Chen 1, 2 , Qingqing Mo 1, 2
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The recurrence of patients with epithelial ovarian cancer (EOC) is largely attributed to tumour cells escaping from the surveillance of immune cells. However, to date there is a lack of studies that have systematically evaluated the associations between the infiltration fraction of immune cells and the recurrence risk of EOC. Based on the micro-ribonucleic acid (microRNA) expression profiles of 441 EOC patients, we constructed a microRNA-based panel with recurrence prediction potential using non-negative matrix factorization consensus clustering. Then, we evaluated the association between recurrence risk and infiltration proportions among 10 immune cell types by CIBERSORT and a multivariable Cox regression model. As a result, we identified a 72-microRNA-based panel that could stratify patients into high and low risk of recurrence. The infiltration of plasma cells and M1 macrophages was consistently significantly associated with the risk of recurrence in patients with EOC. Plasma cells were significantly associated with a decreased risk of relapse [hazard ratio (HR) = 0.58, p = 0.006), while M1 macrophages were associated with an increased risk of relapse (HR = 1.59, p = 0.003). Therefore, the 72-microRNA-based panel, M1 macrophages and plasma cells may hold potential to serve as recurrence predictors of EOC patients in clinical practice.
中文翻译：
肿瘤浸润淋巴细胞对上皮性卵巢癌复发的预后意义
上皮性卵巢癌（EOC）患者的复发主要归因于肿瘤细胞逃避免疫细胞的监视。然而，迄今为止，还缺乏系统评估免疫细胞浸润分数与 EOC 复发风险之间关系的研究。基于 441 名 EOC 患者的微核糖核酸 (microRNA) 表达谱，我们使用非负矩阵分解共识聚类构建了一个基于 microRNA 的面板，该面板具有复发预测潜力。然后，我们通过 CIBERSORT 和多变量 Cox 回归模型评估了 10 种免疫细胞类型中复发风险和浸润比例之间的关联。因此，我们确定了一个基于 72 个 microRNA 的面板，可以将患者分为高复发风险和低复发风险。浆细胞和 M1 巨噬细胞的浸润始终与 EOC 患者的复发风险显着相关。浆细胞与复发风险降低显着相关[风险比 (HR) = 0.58,p = 0.006），而 M1 巨噬细胞与复发风险增加相关（HR = 1.59，p = 0.003）。因此，基于 72-microRNA 的面板、M1 巨噬细胞和浆细胞可能具有在临床实践中作为 EOC 患者复发预测因子的潜力。
更新日期：2021-06-30
中文翻译：
肿瘤浸润淋巴细胞对上皮性卵巢癌复发的预后意义
上皮性卵巢癌（EOC）患者的复发主要归因于肿瘤细胞逃避免疫细胞的监视。然而，迄今为止，还缺乏系统评估免疫细胞浸润分数与 EOC 复发风险之间关系的研究。基于 441 名 EOC 患者的微核糖核酸 (microRNA) 表达谱，我们使用非负矩阵分解共识聚类构建了一个基于 microRNA 的面板，该面板具有复发预测潜力。然后，我们通过 CIBERSORT 和多变量 Cox 回归模型评估了 10 种免疫细胞类型中复发风险和浸润比例之间的关联。因此，我们确定了一个基于 72 个 microRNA 的面板，可以将患者分为高复发风险和低复发风险。浆细胞和 M1 巨噬细胞的浸润始终与 EOC 患者的复发风险显着相关。浆细胞与复发风险降低显着相关[风险比 (HR) = 0.58,p = 0.006），而 M1 巨噬细胞与复发风险增加相关（HR = 1.59，p = 0.003）。因此，基于 72-microRNA 的面板、M1 巨噬细胞和浆细胞可能具有在临床实践中作为 EOC 患者复发预测因子的潜力。
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