Abstract

5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine 2 was synthesized and employed to synthesize new 1,3,4-thiadiazole and 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives via reactions with variant electrophilic reagents under solvent-free conditions. The chemical structures of these novel compounds were elucidated scrupulously by aiding elemental data and spectroscopic techniques. The synthesized compounds were evaluated for the insecticidal activity against cotton leaf worm (Spodoptera littoralis). It was realized that the insecticidal activity of 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives emerged remarkable results comparable with 1,3,4-thiadiazole derivatives against cotton leafworm (Spodoptera littoralis).

摘要

合成5-(3-氯苯基)-1,3,4-噻二唑-2-胺2并用于合成新的1,3,4-噻二唑和1,3,4-噻二唑并[3,2- a ]嘧啶在无溶剂条件下通过与变体亲电试剂反应生成衍生物。通过辅助元素数据和光谱技术，这些新化合物的化学结构得到了严格的阐明。评价合成的化合物对棉叶虫（Spodoptera littoralis）的杀虫活性。认识到1,3,4-噻二唑并[3,2- a ]嘧啶衍生物对棉叶虫的杀虫活性与1,3,4-噻二唑衍生物相当。斜纹夜蛾）。