Cryptococcus is an encapsulated yeast that causes fungal meningitis, most commonly in HIV patients, with high mortality rates. Thus, the study of new treatment options is relevant. Antifungal activity of organoselenium compounds attributed to their pro-oxidative effect in fungal cells has been shown given that few data regarding its anti-Cryptococcus activity are available, this in vitro study was conducted with 40 clinical isolates of Cryptococcus neoformans. Diphenyl diselenide (DD) alone, and its interaction with amphotericin B or fluconazole, was tested by microdilution and checkerboard assays. All Cryptococcus neoformans were inhibited by DD in concentrations ≤ 32 μg/mL, and fungicidal concentrations were ≤ 64 μg/mL. Advantageous interaction between fluconazole occurred in 40% of the isolates, respectively. This study contributes with data of DD alone and in combination with classical drugs of choice for cryptococcosis treatment. Further studies focused on DD antifungal mechanism of action, and in vivo experiments are necessary.

隐球菌是一种包封酵母，可导致真菌性脑膜炎，最常见于 HIV 患者，死亡率很高。因此，研究新的治疗方案是相关的。有机硒化合物的抗真菌活性归因于它们在真菌细胞中的促氧化作用，鉴于几乎没有关于其抗隐球菌活性的数据，这项体外研究是用 40 种新型隐球菌临床分离株进行的。通过微量稀释法和棋盘法测定单独的二苯基二硒化物 (DD) 及其与两性霉素 B 或氟康唑的相互作用。所有 新型隐球菌DD抑制浓度≤32 μg/mL，杀菌浓度≤64 μg/mL。氟康唑之间的有利相互作用分别发生在 40% 的分离物中。这项研究提供了单独的 DD 数据以及与隐球菌病治疗选择的经典药物联合使用的数据。进一步的研究集中在DD抗真菌的作用机制上，体内实验是必要的。