Non-steroidal anti-inflammatory drugs are widely used to relieve pain, reduce inflammation, high temperature and fever, and prevent blood clots. There are very few studies where some of these drugs are studied simultaneously and their biological effects are compared. Therefore, in this study, commercial formulations of eight different drugs used as analgesic or anti-inflammatory were examined in terms of cell viability or cytotoxicity, antioxidant and antimicrobial activities. The antibiogram resistance pattern was carried out by agar dilution method. All drugs contain one of the components dexketoprofen, diclofenac sodium, meloxicam, metamizole, paracetamol and tramadol hydrochloride as major active ingredients were tested against some human pathogenic bacteria and fungi. Drugs containing metamizole showed high antimicrobial and antifungal effects. The MIC values were ranged from 0.3125 mg/mL to 0.0625 mg/mL for most of the samples and even lower for others. Human bronchial epithelial cells (BEAS-2B) were treated with different concentrations of these drugs for 24, 48 and 72 h. Considering the IC₅₀ values obtained after treatments, cytotoxicity of these drugs was as follows in descending order according to their major active ingredient: diclofenac sodium, meloxicam, dexketoprofen, trometamol, paracetamol and tramadol hydrochloride. MTT results related to metamizole sodium have not been evaluated because the absorbance values will not reflect real results due to the purple color that appears while working on this drug. According to different antioxidative assays performed the drug samples including metamizole sodium and paracetamol have the highest antioxidant activity values.

非甾体类抗炎药被广泛用于缓解疼痛、减轻炎症、高温和发热，防止血栓形成。很少有研究同时研究其中一些药物并比较它们的生物效应。因此，在这项研究中，从细胞活力或细胞毒性、抗氧化和抗微生物活性方面检查了用作镇痛或抗炎药的八种不同药物的商业制剂。抗菌谱抗性模式通过琼脂稀释法进行。所有药物均含有右酮洛芬、双氯芬酸钠、美洛昔康、安乃近、扑热息痛和盐酸曲马多作为主要活性成分之一，对一些人类致病细菌和真菌进行了测试。含有安乃近的药物显示出高度的抗菌和抗真菌作用。大多数样品的 MIC 值范围为 0.3125 mg/mL 至 0.0625 mg/mL，其他样品的 MIC 值甚至更低。人支气管上皮细胞 (BEAS-2B) 用不同浓度的这些药物处理 24、48 和 72 小时。考虑到 IC治疗后获得的_50个值，这些药物的细胞毒性按其主要活性成分降序排列如下：双氯芬酸钠、美洛昔康、右酮洛芬、氨丁三醇、扑热息痛和盐酸曲马多。与安乃近钠相关的 MTT 结果尚未评估，因为吸光度值不会反映实际结果，因为在使用该药物时会出现紫色。根据不同的抗氧化试验，安乃近钠和扑热息痛的药物样品具有最高的抗氧化活性值。