Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery,Mini-Reviews in Medicinal Chemistry

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Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-06-30 , DOI: 10.2174/1389557520666200804124924
Yongzhen Guo ₁ , Xuben Hou ₁ , Hao Fang ₁

Affiliation

Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.

中文翻译：

苯并咪唑在药物发现中作为特权支架的最新应用

苯并咪唑是一种芳香族双环杂环，在药物化学中被认为是一种有价值的特权支架。许多市售的含有苯并咪唑支架的药物和天然产品在对抗各种疾病方面发挥着重要作用，如高血压、消化性溃疡、寄生虫感染和癌症。在这篇综述中，我们介绍了一些已上市药物和先导化合物的药理学应用，重点是抗癌药物，报告了相应的数据以显示其靶点的生物活性。本综述中的出版物包括 2014 年至 2019 年的出版物。

更新日期：2021-07-01

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