Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2021-07-31 , DOI: 10.2174/1570178617999201005211251 Xiao-Yu Zhou 1 , Xia Chen 1
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Pd/C catalyzed decarboxylation-transfer hydrogenation of quinoline carboxylic acids and transfer hydrogenation of quinolines had been developed for the synthesis of 1,2,3,4- tetrahydroquinolines. These two processes were implemented smoothly using Pd/C (0.9 mol%) as a catalyst with ammonium formate as a hydrogen source in ethanol at 80 °C. The reaction system can also be applied to transfer hydrogenation of benzo[h]quinoline and 2,9-dimethyl-1,10- phenanthroline with good to excellent yields. And the gram scale and recycling of catalyst had been tested with good results. Furthermore, the mechanism of Pd/C catalyzed reduction of quinoline carboxylic acids and quinolines had been proposed.
中文翻译：
Pd/C催化的喹啉羧酸的脱羧-转移加氢
Pd/C催化的喹啉羧酸的脱羧-转移加氢和喹啉的转移加氢已被开发用于合成1,2,3,4-四氢喹啉。这两个过程使用 Pd/C (0.9 mol%) 作为催化剂，以甲酸铵作为氢源，在 80 °C 的乙醇中顺利实施。该反应体系也可用于苯并[h]喹啉和2,9-二甲基-1,10-菲咯啉的转移加氢，收率良好。并对催化剂的克级规模和回收利用进行了测试，效果良好。此外，还提出了Pd/C催化还原喹啉羧酸和喹啉的机理。
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