Abstract

Neutrophils are one of the main cells of innate immunity that perform a key effector and regulatory function in the development of the human inflammatory response. Apoptotic forms of neutrophils are important for regulating the intensity of inflammation and restoring tissue homeostasis. This review summarizes current data on the molecular mechanisms of modulation of neutrophil apoptosis by the main regulatory factors of the inflammatory response—cytokines, integrins, and structural components of bacteria. Disturbances in neutrophil apoptosis under stress are also considered, molecular markers of changes in neutrophil lifespan associated with various diseases and pathological conditions are presented, and data on pharmacological agents for modulating apoptosis as potential therapeutics are also discussed.

中文翻译：

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正常和病理条件下调控中性粒细胞凋亡的分子机制

摘要

中性粒细胞是先天免疫的主要细胞之一，在人类炎症反应的发展中发挥关键效应和调节功能。中性粒细胞的凋亡形式对于调节炎症强度和恢复组织稳态很重要。本综述总结了当前关于通过炎症反应的主要调节因子——细胞因子、整合素和细菌结构成分调节中性粒细胞凋亡的分子机制的数据。还考虑了应激条件下嗜中性粒细胞凋亡的紊乱，介绍了与各种疾病和病理状况相关的嗜中性粒细胞寿命变化的分子标记，还讨论了作为潜在疗法的调节细胞凋亡的药物数据。