Abstract

Currently, most researchers believe that circannual fluctuations in the functioning of the human body relate not so much to fluctuations in melatonin levels as to changes in the ambient temperature. The goal of this work was to study the seasonal dynamics of melatonin, prolactin, sex hormones, and adrenal hormones in healthy people by a meta-analysis of publications and, based on its outcome, to draw a conclusion on the influence of the photoperiod and air temperature on seasonal changes in the functioning of the organism of modern humans. Using Review Manager 5.3, we carried out a meta-analysis of 31 panel and 12 cross-sectional studies devoted to the seasonal dynamics of circulating hormones. We found that the level of circulating norepinephrine and aldosterone increases in winter compared to summer, which, along with the previously established winter increase in the activity of thyroid hormones, corroborates the significant effect of circannual air temperature fluctuations on the hormonal status of modern humans. However, since a number of studies have shown the seasonal dynamics of melatonin, while our meta-analysis revealed a significant increase in the diurnal average prolactin level in women of reproductive age in spring compared to fall, the influence of the photoperiod on our contemporaries cannot be ruled out completely. Hormonal changes, in turn, can cause seasonal changes in physiological parameters and reproductive functions, as well as affect the development and exacerbation of certain pathologies.

中文翻译：

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健康人褪黑激素、催乳素、性激素和肾上腺激素的季节性动态：元分析

摘要

目前，大多数研究人员认为，人体机能的周期性波动与其说是与褪黑激素水平的波动有关，不如说是与环境温度的变化有关。这项工作的目的是通过对出版物的荟萃分析来研究健康人褪黑激素、催乳素、性激素和肾上腺激素的季节性动态，并根据其结果得出关于光周期和气温对现代人类有机体功能的季节性变化的影响。使用 Review Manager 5.3，我们对 31 个小组和 12 个横断面研究进行了荟萃分析，这些研究致力于循环激素的季节性动态。我们发现，与夏季相比，冬季循环去甲肾上腺素和醛固酮的水平增加，随着先前确定的冬季甲状腺激素活性增加，证实了昼夜气温波动对现代人类荷尔蒙状况的显着影响。然而，由于大量研究显示了褪黑激素的季节性动态，而我们的荟萃分析显示，与秋季相比，春季育龄妇女的昼夜平均催乳素水平显着增加，光周期对我们同时代人的影响不能完全排除。反过来，荷尔蒙的变化会导致生理参数和生殖功能的季节性变化，并影响某些病理的发展和恶化。证实了全年气温波动对现代人类荷尔蒙状况的显着影响。然而，由于大量研究显示了褪黑激素的季节性动态，而我们的荟萃分析显示，与秋季相比，春季育龄妇女的昼夜平均催乳素水平显着增加，光周期对我们同时代人的影响不能完全排除。反过来，荷尔蒙变化会导致生理参数和生殖功能的季节性变化，并影响某些病理的发展和恶化。证实了全年气温波动对现代人类荷尔蒙状况的显着影响。然而，由于大量研究显示了褪黑激素的季节性动态，而我们的荟萃分析显示，与秋季相比，春季育龄妇女的昼夜平均催乳素水平显着增加，光周期对我们同时代人的影响不能完全排除。反过来，荷尔蒙变化会导致生理参数和生殖功能的季节性变化，并影响某些病理的发展和恶化。虽然我们的荟萃分析显示，与秋季相比，春季育龄妇女的昼夜平均催乳素水平显着增加，但不能完全排除光周期对我们同时代人的影响。反过来，荷尔蒙变化会导致生理参数和生殖功能的季节性变化，并影响某些病理的发展和恶化。虽然我们的荟萃分析显示，与秋季相比，春季育龄妇女的昼夜平均催乳素水平显着增加，但不能完全排除光周期对我们同时代人的影响。反过来，荷尔蒙变化会导致生理参数和生殖功能的季节性变化，并影响某些病理的发展和恶化。