ABSTRACT

Microwave-activated synthesis is a special and remarkable technique in modern synthetic organic chemistry. In the current research, it is described the microwave-assisted synthesis of 2-aryl-4,5-dicarbonitrile imidazole derivatives via a one-step reaction between aromatic aldehydes and 2,3-diaminomaleonitrile (DAMN) using HNO₃ as a metal-free catalyst and a strong oxidizing agent. The present methodology has significant advantages as like as one-step synthesis, shorter reaction times, available starting materials, and higher yields of products with easy purification process, cleaner reaction than the previously reported processes. The valuable benefits of this method have provided a promising prospect for easier, greener, and faster synthesis of diciano imidazoles.

摘要

微波活化合成是现代有机合成化学中一项特殊而卓越的技术。在目前的研究中，描述了使用 HNO ₃作为金属，通过芳香醛和 2,3-二氨基马来腈 (DAMN) 之间的一步反应，微波辅助合成 2-芳基-4,5-二甲腈咪唑衍生物。游离催化剂和强氧化剂。本方法具有显着的优势，如一步合成、更短的反应时间、可用的起始材料、产品的产率更高、纯化过程容易、反应比以前报道的过程更清洁。这种方法的宝贵优势为更容易、更环保、更快速地合成二苯并咪唑提供了广阔的前景。