Pharmaceutical Biology ( IF 3.9 ) Pub Date : 2021-07-01 , DOI: 10.1080/13880209.2021.1942925 Titeyut Wongsanao 1 , Wipavadee Leemingsawat 1 , Vipaporn Panapisal 2 , Thanomwong Kritpet 1
Abstract
Context
Psidium guajava L. (Myrtaceae) leaf contains a wide variety of bioactive compounds that contribute valuable effects on human well-being.
Objective
This study investigates the influence of guava leaf extract-menthol toner on thermoregulation, including perspiration, skin temperature, and recovery heart rate.
Materials and methods
This randomised, placebo-controlled clinical trial assessed the effects of the guava leaf extract-menthol toner and placebo with a 1-week washout period. Sixty-four participants were enrolled. The participants exercised on a treadmill until a 75% heart rate reserve was achieved for 5 min, followed by a 5 min post-exercise rest period. The skin temperature and heart rate were then measured before 5 mL of the testing product was sprayed to specific areas of the body, left it for 30 sec before wiped off. Post-exercise perspiration and skin temperatures were collected by sweat patches and measured by the Skin-thermometer ST500, respectively. A 20 min heart rate monitoring period started 10 min after the exercise and measured every 2 min intervals.
Results
Use of the toner significantly reduced post-exercise perspiration to approximately half of the baseline and placebo use values (p < 0.05). Furthermore, relative heart rate changes showed no significant differences among the tests (p > 0.05). Skin temperature was also unaffected (p > 0.05).
Discussion and Conclusion
Guava leaf extract-menthol toner reduced perspiration by astringent effects but did not influence heat dissipation and did not affect cardiovascular mechanism compared to the controls. Additional cleaning with guava leaf extract-menthol toner could offer better hygiene after a workout.
中文翻译:
番石榴叶提取物-薄荷醇爽肤水在运动后使用的体温调节作用
摘要
语境
Psidium guajava L.(桃金娘科)叶含有多种生物活性化合物,对人类福祉有重要影响。
客观的
本研究调查了番石榴叶提取物-薄荷醇爽肤水对体温调节的影响,包括出汗、皮肤温度和恢复心率。
材料和方法
这项随机的、安慰剂对照的临床试验评估了番石榴叶提取物-薄荷醇爽肤水和安慰剂的效果,清除期为 1 周。六十四名参与者被录取。参与者在跑步机上锻炼,直到 5 分钟达到 75% 的心率储备,然后是锻炼后 5 分钟的休息时间。然后测量皮肤温度和心率,然后将 5 mL 测试产品喷洒到身体的特定区域,放置 30 秒后擦去。运动后的汗水和皮肤温度分别通过汗斑收集并通过皮肤温度计 ST500 进行测量。运动后 10 分钟开始 20 分钟的心率监测期,每隔 2 分钟测量一次。
结果
使用爽肤水可显着减少运动后的出汗量,约为基线和安慰剂使用值的一半(p < 0.05)。此外,相对心率变化在测试之间没有显着差异(p > 0.05)。皮肤温度也不受影响(p > 0.05)。
讨论与结论
与对照组相比,番石榴叶提取物-薄荷醇爽肤水通过收敛作用减少汗水,但不影响散热,也不影响心血管机制。使用番石榴叶提取物薄荷醇爽肤水进行额外清洁可以在锻炼后提供更好的卫生。