Cardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1–3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery. We performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic. CMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children. Children prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.

中文翻译：

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有症状的 COVID-19 或 MIS-C 康复后儿童的心血管磁共振成像：一项前瞻性研究


儿童感染 SARS-CoV-2 后的中期恢复期间需要进行心脏评估，包括心血管磁共振 (CMR) 成像和生物标志物结果。康复后 1-3 个月 CMR 异常的发生率在老年人中超过 50%，在大学运动员中这一比例在 1% 到 15% 之间。心脏生物标志物异常在成年人中很常见，即使在康复期间也是如此。我们在前瞻性招募的从 COVID-19 和儿童多系统炎症综合征 (MIS-C) 中康复的儿科队列中进行了 CMR 成像。我们获得了 CMR 数据和血清生物标志物。我们将这些结果与年龄匹配的对照患者进行了比较，这些对照患者在 SARS-CoV-2 大流行之前进行了成像。对 17 名儿童（13.9 岁，全部≤ 18 岁）和 29 名年龄匹配的未感染 SARS-CoV-2 的对照患者进行了 CMR。招募有症状的 COVID-19（11/17，65%）或 MIS-C（6/17，35%）病例，并在诊断后平均进行 2 个月的研究。所有 COVID-19 患者在感染期间均出现发烧（73%）、呕吐/腹泻（64%）或呼吸困难（55%）的症状。病例和对照之间的左心室和右心室射血分数无法区分（分别为 p = 0.66 和 0.70）。平均天然整体 T1、整体 T2 值和节段 T2 最大值也与对照患者无统计学差异（均 p ≥ 0.06）。所有儿童的 NT-proBNP 和肌钙蛋白水平均正常。 SARS-CoV-2 感染后前瞻性招募的儿童在中期恢复期间 CMR 和心脏生物标志物评估均正常。试用注册 不适用。