Antarctic bacteria are able to survive under extreme environmental conditions and have adapted to exploit some of the most ephemeral nutrient pockets. Importantly, such strains have been often shown to be capable of synthesizing compounds of valuable biotechnological importance. Here we show that Pseudomonas sp. TAE6080, a possibly new bacterium isolated in 1994 during water column samplings near the French Antarctic station Dumont d'Urville, is capable of inhibiting the formation of Staphylococcus epidermidis biofilm, known to be an important opportunistic pathogen in infections associated to medical devices. A better understanding of this bacterium can therefore provide useful insight on new bioactive molecules that could play a role against chronic infections. To this end, the anti-biofilm effect of cell-free supernatant of Pseudomonas sp. TAE6080 was evaluated on S. epidermidis RP62A biofilm formation, demonstrating that it significantly reduced its aggregation. Furthermore, genome sequencing, assembly and mining revealed a plethora of putative biosynthetic gene clusters that might be involved in biofilm disruption. The experimental and genomic data presented here open the venue to further investigations on the molecular basis underlying biofilm inhibition.

南极细菌能够在极端环境条件下生存，并且已经适应利用一些最短暂的营养袋。重要的是，此类菌株经常被证明能够合成具有重要生物技术重要性的化合物。在这里，我们展示了假单胞菌属。TAE6080 可能是 1994 年在法国南极站 Dumont d'Urville 附近水柱取样期间分离出的一种新细菌，能够抑制表皮葡萄球菌的形成生物膜，已知是与医疗器械相关的感染的重要机会病原体。因此，更好地了解这种细菌可以为可能对慢性感染发挥作用的新生物活性分子提供有用的见解。为此，假单胞菌属无细胞上清液的抗生物膜作用。TAE6080 对表皮葡萄球菌RP62A 生物膜形成进行了评估，表明它显着减少了其聚集。此外，基因组测序、组装和挖掘揭示了大量可能与生物膜破坏有关的假定生物合成基因簇。这里提供的实验和基因组数据为进一步研究生物膜抑制的分子基础开辟了道路。