Purpose of Review

Current therapeutic strategies to mitigate heart failure progression after myocardial infarction involve support of endogenous repair through molecular targets. The capacity for repair varies greatly between individuals. In this review, we will assess how cardiac PET/CT enables precise characterization of early pathogenetic processes which govern ventricle remodeling and progression to heart failure.

Recent Findings

Inflammation in the first days after myocardial infarction predicts subsequent functional decline and can influence therapy decisions. The expansion of anti-inflammatory approaches to improve outcomes after myocardial infarction may benefit from noninvasive characterization using imaging. Novel probes also allow visualization of fibroblast transdifferentiation and activation, as a precursor to ventricle remodeling.

Summary

The expanding arsenal of molecular imaging agents in parallel with new treatment options provides opportunity to harmonize diagnostic imaging with precision therapy.

中文翻译：

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使用心脏 PET/CT 进行分子成像：协调诊断和治疗的机会

 审查目的

目前减轻心肌梗死后心力衰竭进展的治疗策略涉及通过分子靶点支持内源性修复。修复能力因人而异。在这篇综述中，我们将评估心脏 PET/CT 如何精确表征控制心室重塑和心力衰竭进展的早期发病过程。

 最近的发现

心肌梗塞后最初几天的炎症预示着随后的功能衰退，并可能影响治疗决策。扩大抗炎方法以改善心肌梗死后的预后可能会受益于使用成像的无创表征。新型探针还可以可视化成纤维细胞转分化和激活，作为心室重塑的前兆。

 概括

分子成像剂库的不断扩大与新的治疗选择相结合，为协调诊断成像与精准治疗提供了机会。