AIM To perform a scoping literature review of associations between risk factors in early life and developmental coordination disorder (DCD). METHOD PubMed, Embase, CINAHL, PsycINFO, and Web of Science (January 1994-March 2019) were searched to identify studies on early risk factors and motor impairment or DCD. The effect of single and multiple risk factors was assessed. Level of evidence was evaluated following the Centre for Evidence-Based Medicine guidelines. Meta-analysis on the effect of preterm birth was performed. RESULTS Thirty-six studies fulfilled inclusion criteria; 35 had evidence level 3, one had level 4. Highest evidence was available that preterm birth and male sex in term-born children were associated with DCD. The odds ratio of preterm birth was 2.02 (95% confidence interval: 1.43-2.85). Low to moderate evidence was available that parental subfertility, maternal smoking during pregnancy, postnatal corticosteroid treatment in infants born preterm, extra corporeal membrane oxygenation, retinopathy of prematurity, abnormalities on magnetic resonance imaging scans at term age, and accumulating perinatal or neonatal risk factors were associated with motor impairment. INTERPRETATION Limited information on early risk factors of DCD is available. Only preterm birth and male sex were consistently associated with an increased risk of DCD.

中文翻译：

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发育性协调障碍的早期危险因素：范围审查

目的 对早期生活中的危险因素与发育性协调障碍 (DCD) 之间的关联进行范围界定文献回顾。方法检索了 PubMed、Embase、CINAHL、PsycINFO 和 Web of Science（1994 年 1 月至 2019 年 3 月），以确定有关早期风险因素和运动障碍或 DCD 的研究。评估了单个和多个风险因素的影响。根据循证医学中心指南评估证据水平。对早产的影响进行了荟萃分析。结果 36 项研究符合纳入标准；35 人有 3 级证据，1 人有 4 级证据。最高证据表明早产和早产儿男性与 DCD 相关。早产的优势比为 2.02（95% 置信区间：1.43-2.85）。低至中等证据表明，父母生育能力低下、母亲怀孕期间吸烟、早产婴儿的产后皮质类固醇治疗、体外膜氧合、早产儿视网膜病变、足月磁共振成像扫描异常以及围产期或新生儿风险因素的积累是与运动障碍有关。解释 关于 DCD 早期危险因素的信息有限。只有早产和男性始终与 DCD 风险增加相关。围产期或新生儿风险因素的积累与运动障碍有关。解释 关于 DCD 早期危险因素的信息有限。只有早产和男性始终与 DCD 风险增加相关。围产期或新生儿风险因素的积累与运动障碍有关。解释 关于 DCD 早期危险因素的信息有限。只有早产和男性始终与 DCD 风险增加相关。