Across disciplines, there is great anticipation that evolving cell therapies may finally provide a therapeutic option for conditions in dire need. These conditions are typically complex and their pathophysiology incompletely understood, hindering the development of robust preclinical models and the precise assessment of therapeutic effects in human studies. This article provides an overview of the status of cell therapy investigations in two common neurodevelopmental disorders, cerebral palsy and autism spectrum disorder. Challenges facing this line of study, including inherent heterogeneity, knowledge gaps, and unrealistic expectations, are discussed. Much progress has been made in the past decade, but to definitively determine if cell therapies have a role in the treatment of neurodevelopmental disorders, both fields will need to evolve together.

中文翻译：

---

脑瘫和自闭症谱系障碍的干细胞疗法

跨学科，人们非常期待不断发展的细胞疗法可能最终为急需的疾病提供治疗选择。这些情况通常很复杂，其病理生理学尚未完全了解，阻碍了稳健的临床前模型的开发和人体研究中治疗效果的精确评估。本文概述了两种常见神经发育障碍（脑瘫和自闭症谱系障碍）的细胞疗法研究现状。讨论了这一研究领域面临的挑战，包括固有的异质性、知识差距和不切实际的期望。在过去十年中取得了很大进展，但要确定细胞疗法是否在神经发育障碍的治疗中发挥作用，这两个领域都需要共同发展。