AIM To investigate the relation between cognitive and motor development in preschool aged children with Dravet syndrome, in particular between the age of independent walking and cognitive development. METHOD Results of cognitive and motor developmental assessments and the age of independent walking were retrieved retrospectively from the medical records of 33 children (17 males, 16 females; mean age at last evaluation 33.2mo, SD 8.2mo, range 9-48mo) diagnosed with Dravet syndrome. Cognitive and motor developmental age, derived from the Bayley Scales of Infant Development or through standardized neurodevelopmental assessment, were converted into cognitive and motor developmental quotients. Multiple test scores per child were included. RESULTS A strong positive relation was found between cognitive and motor developmental quotient (Pearson r=0.854; p<0.001) in 20 children (slope=0.75; 95% CI: 0.54-0.95). A later age of independent walking was associated with a lower cognitive developmental quotient (28 children; p<0.001; slope=-1.01; 95% CI: -1.53 to -0.49). A higher cognitive developmental quotient was seen in children with an age at testing younger than 24 months. The cognitive developmental quotient of children with a delay in independent walking (>17.6mo) was significantly lower than those without a delay (p=0.006). INTERPRETATION A strong relation exists between cognitive and motor development. Furthermore, the age of independent walking might be an important indicator of the development of children with Dravet syndrome.

中文翻译：

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Dravet综合征学龄前儿童的独立行走和认知发展

目的探讨Dravet综合征学龄前儿童认知与运动发育的关系，特别是独立行走年龄与认知发育的关系。方法 从 33 名儿童（男 17 名，女 16 名；上次评估平均年龄 33.2 个月，SD 8.2 个月，范围 9-48 个月）的病历中回顾性检索认知和运动发育评估结果以及独立行走的年龄。 Dravet 综合征。从贝利婴儿发育量表或通过标准化神经发育评估得出的认知和运动发育年龄被转换为认知和运动发育商数。包括每个孩子的多项考试成绩。结果发现认知和运动发育商之间存在很强的正相关关系（Pearson r=0.854；p<0.001）在 20 名儿童中（斜率 = 0.75；95% CI：0.54-0.95）。较晚的独立行走年龄与较低的认知发育商相关（28 名儿童；p<0.001；斜率 =-1.01；95% CI：-1.53​​ 至 -0.49）。在测试年龄小于 24 个月的儿童中观察到更高的认知发展商数。独立行走延迟（>17.6mo）儿童的认知发育商显着低于没有延迟的儿童（p = 0.006）。解释 认知和运动发展之间存在很强的关系。此外，独立行走的年龄可能是 Dravet 综合征儿童发育的重要指标。较晚的独立行走年龄与较低的认知发展商相关（28 名儿童；p<0.001；斜率 =-1.01；95% CI：-1.53​​ 至 -0.49）。在测试年龄小于 24 个月的儿童中观察到更高的认知发展商数。独立行走延迟（>17.6mo）儿童的认知发育商显着低于没有延迟的儿童（p = 0.006）。解释 认知和运动发展之间存在很强的关系。此外，独立行走的年龄可能是 Dravet 综合征儿童发育的重要指标。较晚的独立行走年龄与较低的认知发展商相关（28 名儿童；p<0.001；斜率 =-1.01；95% CI：-1.53​​ 至 -0.49）。在测试年龄小于 24 个月的儿童中观察到更高的认知发展商数。独立行走延迟（>17.6mo）儿童的认知发育商显着低于没有延迟的儿童（p = 0.006）。解释 认知和运动发展之间存在很强的关系。此外，独立行走的年龄可能是 Dravet 综合征儿童发育的重要指标。独立行走延迟（>17.6mo）儿童的认知发育商显着低于没有延迟的儿童（p = 0.006）。解释 认知和运动发展之间存在很强的关系。此外，独立行走的年龄可能是 Dravet 综合征儿童发育的重要指标。独立行走延迟（>17.6mo）儿童的认知发育商显着低于没有延迟的儿童（p = 0.006）。解释 认知和运动发展之间存在很强的关系。此外，独立行走的年龄可能是 Dravet 综合征儿童发育的重要指标。