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Influence of socioeconomic status on cognitive outcome after childhood arterial ischemic stroke
Developmental Medicine & Child Neurology ( IF 3.8 ) Pub Date : 2020-12-18 , DOI: 10.1111/dmcn.14779
Lisa Bartha‐Doering 1, 2 , Andreas Gleiss 3 , Sarah Knaus 1, 2 , Maria Theresa Schmook 4 , Rainer Seidl 1, 2
Affiliation  

AIM To determine whether socioeconomic status (SES) is a stronger predictor for cognitive outcome after childhood arterial ischemic stroke compared to clinical factors. METHOD We investigated perceptual reasoning, executive functions, language, memory, and attention in 18 children and adolescents (12 males, six females, median age at testing 13y 4mo, range 7y-17y 5mo) after arterial ischemic stroke; collected sociodemographic information (education of parents, household income); and used clinical information (initial lesion volume, residual lesion volume, age at stroke, time since stroke). Linear regression models were used to investigate the potential influence of SES and clinical parameters on cognitive abilities. RESULTS SES had a moderate effect on all cognitive outcome parameters except attention by explaining 41.9%, 37.9%, 38.0%, and 22.5% of variability in perceptual reasoning, executive functions, language, and memory respectively. Initial lesion volume was the only clinical parameter that showed moderate importance on cognitive outcome (33.1% and 25.6% of the variability in perceptual reasoning and memory respectively). Overall, SES was a stronger predictor of cognitive outcome than clinical factors. INTERPRETATION Future paediatric studies aiming at clinical predictors of cognitive outcome should control their analyses for SES in their study participants. The findings of the present study further point to the need for more attention to the treatment of children with low SES.

中文翻译:

社会经济地位对儿童动脉缺血性卒中后认知结局的影响

目的 确定与临床因素相比,社会经济地位 (SES) 是否更能预测儿童动脉缺血性卒中后的认知结果。方法 我们调查了动脉缺血性卒中后 18 名儿童和青少年(12 名男性,6 名女性,测试时的中位年龄 13 岁 4 个月,范围 7 岁至 17 岁 5 个月)的感知推理、执行功能、语言、记忆和注意力;收集的社会人口信息(父母的教育、家庭收入);和使用的临床信息(初始病灶体积、残留病灶体积、中风年龄、中风后时间)。线性回归模型用于研究 SES 和临床参数对认知能力的潜在影响。结果 通过解释 41.9%、37.9%、38.0% 和 22,SES 对除注意力以外的所有认知结果参数都有中等影响。感知推理、执行功能、语言和记忆的变异性分别为 5%。初始病变体积是唯一对认知结果显示中等重要性的临床参数(感知推理和记忆的变异性分别为 33.1% 和 25.6%)。总体而言,SES 是比临床因素更能预测认知结果的因素。解释 未来针对认知结果的临床预测因子的儿科研究应该控制他们对研究参与者的 SES 分析。本研究的结果进一步表明需要更多地关注低 SES 儿童的治疗。分别为感知推理和记忆的 1% 和 25.6% 的可变性)。总体而言,SES 是比临床因素更能预测认知结果的因素。解释 未来针对认知结果的临床预测因子的儿科研究应该控制他们对研究参与者的 SES 分析。本研究的结果进一步表明需要更多地关注低 SES 儿童的治疗。分别为感知推理和记忆的 1% 和 25.6% 的可变性)。总体而言,SES 是比临床因素更能预测认知结果的因素。解释 未来针对认知结果的临床预测因子的儿科研究应该控制他们对研究参与者的 SES 分析。本研究的结果进一步表明需要更多地关注低 SES 儿童的治疗。
更新日期:2020-12-18
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