AIM To evaluate the sensitivity, specificity, and predictive value of the Hand Assessment for Infants (HAI) in identifying infants at risk of being diagnosed with unilateral cerebral palsy (CP), and to determine cut-off values for this purpose. METHOD A convenience sample of 203 infants (106 females, 97 males) was assessed by the HAI at 3, 6, 9, and 12 months. Sensitivity, specificity, predictive values, and likelihood ratios were calculated using receiver operating characteristic curve analysis. Cut-off values were derived for different ages. The clinical outcome (unilateral CP yes/no) at 24 months or more served as an external criterion to investigate the predictive validity of HAI. RESULTS Half of the infants developed unilateral CP. The area under the curve ranged from 0.77 (95% CI [confidence interval] 0.63-0.91) to 0.95 (95% CI 0.90-1.00) across HAI scales and age intervals. Likewise, sensitivity ranged from 63% to 93%, specificity from 62% to 91%, and accuracy from 73% to 94%. INTERPRETATION HAI scores demonstrated overall accuracy that ranged from very good to excellent in predicting unilateral CP in infants at risk aged between 3.5 and 12 months. This accuracy increased with age at assessment and the earliest possible prediction was at 3.5 months of age, when appropriate HAI cut-off values for different ages were applied.

中文翻译：

---

手部评估对单侧脑瘫风险婴儿的预测效度

目的 评估婴儿手部评估 (HAI) 在识别有被诊断为单侧脑瘫 (CP) 风险的婴儿方面的敏感性、特异性和预测价值，并为此确定临界值。方法 在 3、6、9 和 12 个月时，HAI 对 203 名婴儿（106 名女性，97 名男性）的便利样本进行了评估。使用受试者操作特征曲线分析计算敏感性、特异性、预测值和似然比。临界值是针对不同年龄得出的。24 个月或更长时间的临床结果（单侧 CP 是/否）作为研究 HAI 预测有效性的外部标准。结果 一半的婴儿发展为单侧 CP。曲线下面积从 0.77（95% CI [置信区间] 0.63-0.91）到 0.95（95% CI 0.90-1。00) 跨 HAI 量表和年龄间隔。同样，敏感性为 63% 至 93%，特异性为 62% 至 91%，准确度为 73% 至 94%。解释 HAI 评分显示出在预测 3.5 至 12 个月之间有风险的婴儿的单侧 CP 方面的总体准确性从非常好到非常好。这种准确性随着评估年龄的增长而增加，最早可能的预测是在 3.5 个月大时，此时应用了不同年龄的适当 HAI 临界值。