AIM To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies. METHOD Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies. RESULTS Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies. INTERPRETATION In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention.

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新生儿后获得性脑瘫患儿的先天性异常：一项国际数据关联研究

目的 描述新生儿后获得性脑瘫 (CP) 儿童存在的主要先天性异常，并比较有和无异常儿童的新生儿后获得性脑瘫 (CP) 的临床结果和病因。方法 将 1991 年至 2009 年出生的五个欧洲和三个澳大利亚地区的总人口 CP 与先天性异常登记册之间的数据联系起来（n = 468 名新生儿后天获得性 CP 儿童；255 名男性，213 名女性）。汇总数据，并根据先天性异常的类型将儿童分为相互排斥的类别。计算了先天性异常儿童的比例。比较有和没有异常的儿童的临床结果和新生儿后获得性 CP 的原因。结果 25 人报告了严重的先天性异常。6%（95% 置信区间 [CI] 21.7-29.9）患有新生儿后天获得性 CP 的儿童。14.5% 的新生儿后天获得性 CP 患儿常有严重的心脏异常。先天性异常儿童的临床结果并不比没有异常的儿童更严重。新生儿后天获得性 CP 的原因因先天性异常的存在而异，异常组中以脑血管意外为主。在 77% 的异常儿童中，先天性异常可能与新生儿后获得性 CP 的原因有关。解释 在这项针对新生儿后获得性 CP 儿童的大型国际研究中，先天性异常（尤其是心脏异常）很常见。