AIM To investigate the efficacy of a virtual reality rehabilitation system of wearable multi-inertial sensors to improve upper-limb function in children with brain injury. METHOD Eighty children (39 males, 41 females) with brain injury including cerebral palsy aged 3 to 16 years (mean age 5y 8mo, SD 2y 10mo) were assessed as part of a multicentre, single-blind, randomized controlled trial. The intervention group received a 30-minute virtual reality intervention and a 30-minute session of conventional occupational therapy while the control group received 60 minutes of conventional occupational therapy per session, with 20 sessions over 4 weeks. The virtual reality rehabilitation system consisted of games promoting wrist and forearm articular movements using wearable inertial sensors. The Melbourne Assessment of Unilateral Upper Limb Function-2 (MA-2), Upper Limb Physician's Rating Scale, Pediatric Evaluation of Disability Inventory Computer Adaptive Test, and computerized three-dimensional motion analysis were performed. RESULTS Both groups (virtual reality, n=40; control, n=38) significantly improved after treatment compared to baseline; however, the virtual reality group showed more significant improvements in upper-limb dexterity functions (MA-2, virtual reality group: Δ=10.09±10.50; control: Δ=3.65±6.92), performance of activities of daily living, and forearm supination by kinematic analysis (p<0.05). In the virtual reality group, children with more severe motor impairment showed significant improvements compared to those with less severe impairment. INTERPRETATION The virtual reality rehabilitation system used in this study, which consists of wearable inertial sensors and offers intensive, interactive, and repetitive motor training, is effective in children with brain injury.

中文翻译：

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脑损伤儿童的虚拟现实康复：一项随机对照试验

目的探讨可穿戴多惯性传感器虚拟现实康复系统改善脑损伤患儿上肢功能的疗效。方法 作为一项多中心、单盲、随机对照试验的一部分，对 80 名患有脑损伤的儿童（39 名男性，41 名女性）进行了评估，其中包括 3 至 16 岁（平均年龄 5 岁 8 个月，SD 2 岁 10 个月）的脑瘫。干预组接受 30 分钟的虚拟现实干预和 30 分钟的常规作业疗法，而对照组每节接受 60 分钟的常规作业疗法，4 周内进行 20 次疗程。虚拟现实康复系统包括使用可穿戴惯性传感器促进手腕和前臂关节运动的游戏。进行了墨尔本单侧上肢功能评估 - 2 (MA-2)、上肢医师评定量表、残疾清单计算机自适应测试的儿科评估和计算机化三维运动分析。结果 与基线相比，两组（虚拟现实，n=40；对照组，n=38）治疗后显着改善；然而，虚拟现实组在上肢灵巧功能（MA-2，虚拟现实组：Δ=10.09±10.50；对照组：Δ=3.65±6.92）、日常生活活动表现和前臂旋后方面表现出更显着的改善通过运动学分析（p<0.05）。在虚拟现实组中，与运动障碍较轻的儿童相比，运动障碍较严重的儿童表现出显着改善。