We address Turkheimer’s argument that genome-wide association studies of behaviors and psychiatric traits will fail to produce coherent explanations. We distinguish two major sources of potential incoherence (heterogeneity and complexity), showing how they independently threaten coherence and considering how they are being and might better be addressed with protein and other databases and network tools.

中文翻译：

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悲观的前景和过山车：在全基因组关联研究中寻找一致性

我们解决了 Turkheimer 的论点，即行为和精神特征的全基因组关联研究将无法产生连贯的解释。我们区分了潜在不连贯性的两个主要来源（异质性和复杂性），展示了它们如何独立地威胁连贯性，并考虑如何使用蛋白质和其他数据库和网络工具更好地解决它们。