Background: While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited. Methods: We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998–2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer. Results: During 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94–1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes. Conclusions: We did not observe any association between periodontal disease and breast cancer risk. Impact: Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.

中文翻译：

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牙周病和乳腺癌风险：护士健康研究的结果

背景：虽然牙周病与癌症风险增加有关，但关于与乳腺癌相关的研究有限。方法：我们在一项大型前瞻性队列研究——护士健康研究（1998-2014）中检查了自我报告的牙周骨丢失诊断与乳腺癌发病率之间的关系。我们使用 Cox 比例风险模型计算了 HR，调整了牙周病和乳腺癌共有的风险因素。结果：在 1,023,647 人年的随访中，报告了 5,110 例乳腺癌病例。我们观察到牙周病与总体乳腺癌风险之间没有关联（HR，1.02；95% 置信区间：0.94-1.10）；这种关联并未因吸烟状况、其他乳腺癌风险因素或乳腺癌亚型而改变。结论：我们没有观察到牙周病与乳腺癌风险之间的任何关联。影响：鉴于文献中的不一致发现，有必要对牙周炎的标准化临床测量进行进一步研究。