Biofilm plays a vital role in the pathogenicity and resistance of bacteria, and is an important problem to be settled urgently in the treatment of bacterial diseases. Exploring effective strategies to control bacterial biofilm has become a hot research topic. Compared to other measures, organic nanomaterials have shown greater prospects in overcoming the problems of bacterial biofilms due to their unique properties. In order to explore more effective organic nanomaterials against biofilms, we used relevant keywords to search for related published publications on the Web of Science . On the basis of these searched publications, this review firstly summarized the properties, formulation, harmness, and treatment challenges of biofilm. Secondly, the current progress of organic nanomaterials against bacterial biofilm and its possible anti-biofilm mechanisms (e.g., reducing the adhesion of biofilms, enhancing the permeability of antimicrobial agents, maintaining drug stability, fighting against biofilm using specific actions) was analyzed. Thirdly, the influences on the anti-biofilm efficacy of organic nanomaterials were discussed from nanoparticles and biofilm characteristics. Finally, the challenges and prospects of organic nanoparticles against biofilm were concluded. This review may help researchers to realize the progress and challenges of nanoparticles against biofilm and thus help to design more efficient organic nanomaterial to fight against biofilms.

生物膜对细菌的致病性和耐药性起着至关重要的作用，是细菌性疾病治疗中亟待解决的重要问题。探索控制细菌生物膜的有效策略已成为一个热门的研究课题。与其他措施相比，有机纳米材料由于其独特的性质在克服细菌生物膜问题方面显示出更大的前景。为了探索更有效的有机纳米材料对抗生物膜，我们使用相关关键词在 Web of Science 上搜索相关已发表的出版物。在这些检索到的出版物的基础上，本综述首先总结了生物膜的特性、配方、危害和治疗挑战。其次，分析了有机纳米材料对抗细菌生物膜的当前进展及其可能的抗生物膜机制（例如，减少生物膜的粘附、增强抗菌剂的渗透性、保持药物稳定性、利用特定作用对抗生物膜）。第三，从纳米颗粒和生物膜特性对有机纳米材料抗生物膜功效的影响进行了讨论。最后，总结了有机纳米粒子对抗生物膜的挑战和前景。该综述可能有助于研究人员了解纳米粒子对抗生物膜的进展和挑战，从而有助于设计更有效的有机纳米材料来对抗生物膜。使用特定动作对抗生物膜）进行了分析。第三，从纳米颗粒和生物膜特性对有机纳米材料抗生物膜功效的影响进行了讨论。最后，总结了有机纳米粒子对抗生物膜的挑战和前景。该综述可能有助于研究人员了解纳米粒子对抗生物膜的进展和挑战，从而有助于设计更有效的有机纳米材料来对抗生物膜。使用特定动作对抗生物膜）进行了分析。第三，从纳米颗粒和生物膜特性对有机纳米材料抗生物膜功效的影响进行了讨论。最后，总结了有机纳米粒子对抗生物膜的挑战和前景。该综述可能有助于研究人员了解纳米粒子对抗生物膜的进展和挑战，从而有助于设计更有效的有机纳米材料来对抗生物膜。