ABSTRACT

A new method is disclosed for the loading and release of doxepin by using gold nanoparticles. It is suggested that loading of doxepin occurs through two Van der Waals interactions between the drug molecules and Au nanoparticles as well as formation of an electronic bridge between them. This interaction increases the mean free-path of the free electrons on gold nanoparticles and makes an external plasmon resonance peak at the UV-Vis spectrum. An emitting green light can control the release process, in which its wavelength is close to the wavelength of surface plasmon resonance of Au NPs. Finally, the performed cellular cytoxicity of Au@doxepin NPs (loaded doxepin onto Au nanoparticles) against PC3 prostate cancer cells showed that this nanoparticle has an acceptable cytotoxicity in the concentration range of 5–40 µg/mL.

摘要

公开了一种使用金纳米粒子装载和释放多塞平的新方法。建议通过药物分子和金纳米粒子之间的两个范德华相互作用以及它们之间形成电子桥来加载多塞平。这种相互作用增加了金纳米粒子上自由电子的平均自由程，并在 UV-Vis 光谱上产生了外部等离子体共振峰。发出的绿光可以控制释放过程，其波长接近金纳米粒子的表面等离子体共振波长。最后，Au@doxepin NPs（负载多虑平到金纳米颗粒上）对 PC3 前列腺癌细胞的细胞毒性表明，这种纳米颗粒在 5-40 µg/mL 的浓度范围内具有可接受的细胞毒性。