当前位置: X-MOL 学术Behav. Genet. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Elucidating the Links Between Mother and Father Alcohol Use Disorder and Adolescent Externalizing Psychopathology: A Test of Transmission Specificity Within Competing Factor Structures and Genetic and Environmental Liabilities
Behavior Genetics ( IF 2.6 ) Pub Date : 2021-06-29 , DOI: 10.1007/s10519-021-10072-w
Veronica Oro 1 , H Hill Goldsmith 2 , Kathryn Lemery-Chalfant 1
Affiliation  

Parental alcohol use disorder (AUD) is a substantiated risk factor for adolescent externalizing psychopathology; however, the level of specificity at which risk from parental AUD is transmitted to adolescent offspring should be interrogated further. The current study modeled competing factor structures of psychopathology in a sample of 502 adolescent twin pairs (Mage = 13.24 years) and tested associations with mother and father AUD. The bifactor model exhibited the best fit to the data when contrasted with correlated factors and general factor models. Paternal AUD predicted the externalizing and internalizing correlated factors, the adolescent P-factor but not the residual externalizing and internalizing factors, and the general factor. No significant associations with maternal AUD were noted. Lastly, the latent factors of adolescent psychopathology were all moderately heritable (h2 = 0.44–0.59) and influenced by the nonshared environment. Shared genetic factors primarily explained externalizing and internalizing covariance. Findings suggest that efforts to mitigate risk in offspring of fathers exhibiting AUD require broader approaches that address the full range of adolescent symptomology.



中文翻译:


阐明母亲和父亲酒精使用障碍与青少年外化精神病理学之间的联系:竞争因素结构以及遗传和环境责任内的传播特异性的测试



父母酒精使用障碍(AUD)是青少年外化精神病理学的一个已证实的危险因素;然而,父母 AUD 风险传递给青少年后代的特异性水平应进一步探讨。目前的研究以 502 对青少年双胞胎(M年龄= 13.24 岁)为样本,对精神病理学的竞争因素结构进行了建模,并测试了与母亲和父亲 AUD 的关联。与相关因素和一般因素模型相比,双因素模型表现出对数据的最佳拟合。父亲 AUD 预测了外化和内化相关因素、青少年 P 因素,但不预测残余外化和内化因素以及一般因素。未发现与母亲 AUD 存在显着关联。最后,青少年精神病理学的潜在因素均具有中等遗传性(h 2 = 0.44–0.59),并受到非共享环境的影响。共同的遗传因素主要解释了外化和内化协方差。研究结果表明,要降低父亲患有 AUD 的后代的风险,需要采取更广泛的方法来解决全方位的青少年症状。

更新日期:2021-06-30
down
wechat
bug