Parental alcohol use disorder (AUD) is a substantiated risk factor for adolescent externalizing psychopathology; however, the level of specificity at which risk from parental AUD is transmitted to adolescent offspring should be interrogated further. The current study modeled competing factor structures of psychopathology in a sample of 502 adolescent twin pairs (M_age = 13.24 years) and tested associations with mother and father AUD. The bifactor model exhibited the best fit to the data when contrasted with correlated factors and general factor models. Paternal AUD predicted the externalizing and internalizing correlated factors, the adolescent P-factor but not the residual externalizing and internalizing factors, and the general factor. No significant associations with maternal AUD were noted. Lastly, the latent factors of adolescent psychopathology were all moderately heritable (h² = 0.44–0.59) and influenced by the nonshared environment. Shared genetic factors primarily explained externalizing and internalizing covariance. Findings suggest that efforts to mitigate risk in offspring of fathers exhibiting AUD require broader approaches that address the full range of adolescent symptomology.

父母酒精使用障碍（AUD）是青少年外化精神病理学的一个已证实的危险因素；然而，应进一步探讨父母 AUD 风险传递给青少年后代的特异性水平。目前的研究在 502 对青少年双胞胎（M_{年龄）样本中模拟了精神病理学的竞争因素结构。} = 13.24 岁）并测试了与母亲和父亲 AUD 的关联。与相关因子和一般因子模型相比，双因子模型表现出对数据的最佳拟合。父亲 AUD 预测外化和内化相关因素、青少年 P 因子但不预测残余外化和内化因素以及一般因素。没有注意到与母亲 AUD 的显着关联。最后，青少年精神病理学的潜在因素都是中度遗传的（h ² = 0.44–0.59）并受非共享环境的影响。共同的遗传因素主要解释了外化和内化协方差。研究结果表明，要降低父亲表现出 AUD 的后代风险，需要更广泛的方法来解决所有青少年症状。