Objectives To estimate the change in the standard lipid profile (SLP) of adults diagnosed with ≥3 metabolic syndrome (MetS) factors following aerobic exercise training (AET); and to investigate whether study/intervention covariates are associated with this change. Design Systematic review with univariate meta-analysis and meta-regression. Data sources English language searches of online databases from inception until July 2020. Eligibility criteria (1) Published randomised controlled human trials with study population ≥10 per group; (2) sedentary adults with ≥3 MetS factors but otherwise free of chronic disease, not pregnant/lactating; (3) AET-only intervention with duration ≥12 weeks; and (4) reporting pre–post intervention SLP outcomes. Results Various univariate meta-analyses pooled 48 data sets of 2990 participants. Aerobic exercise training significantly ( P <.001) improved all lipids (mmol/L mean difference ranges, 95% CIs): total cholesterol, –0.19 (–0.26 to –0.12) to –0.29 (−0.36 to –0.21); triglycerides, −0.17 (–0.19 to –0.14) to –0.18 (−0.24 to –0.13); high-density lipoprotein-cholesterol (HDL-C), 0.05 (0.03 to 0.07) to 0.10 (0.05 to 0.15); and low-density lipoprotein-cholesterol (LDL-C), –0.12 (–0.16 to –0.9) to –0.20 (−0.25 to –0.14). Meta-regression showed that intensity may explain change in triglycerides and volume may explain change in HDL-C and LDL-C. Conclusion Aerobic exercise training positively changes the SLP of sedentary and otherwise healthy adults with ≥3 MetS factors. Adjusting AET intervention training variables may increase the effects of AET on triglycerides and HDL-C. PROSPERO registration number CRD42020151925.

中文翻译：

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确定有氧运动训练对具有三种或更多代谢综合征因素的久坐成年人标准血脂的影响大小：随机对照试验的系统评价和荟萃分析


目的 评估被诊断患有 ≥ 3 种代谢综合征 (MetS) 因素的成人在有氧运动训练 (AET) 后标准血脂 (SLP) 的变化；并调查研究/干预协变量是否与这种变化相关。通过单变量荟萃分析和荟萃回归设计系统评价。数据来源 在线数据库的英文检索，从开始到 2020 年 7 月。 资格标准 (1) 已发表的随机对照人体试验，每组研究人群≥10 人； (2) 久坐的成年人，具有 ≥3 个 MetS 因子，但无慢性疾病，未怀孕/哺乳期； (3)仅AET干预，持续时间≥12周； (4) 报告干预前后的 SLP 结果。结果 各种单变量荟萃分析汇集了 2990 名参与者的 48 个数据集。有氧运动训练显着改善所有血脂（mmol/L 平均差异范围，95% CI）（P <.001）：总胆固醇，–0.19（–0.26 至 –0.12）至 –0.29（−0.36 至 –0.21）；甘油三酯，-0.17（-0.19至-0.14）至-0.18（-0.24至-0.13）；高密度脂蛋白胆固醇（HDL-C），0.05（0.03至0.07）至0.10（0.05至0.15）；和低密度脂蛋白胆固醇 (LDL-C)，–0.12（–0.16 至 –0.9）至 –0.20（−0.25 至 –0.14）。荟萃回归表明，强度可以解释甘油三酯的变化，体积可以解释 HDL-C 和 LDL-C 的变化。结论 有氧运动训练可积极改变久坐和具有 ≥ 3 个 MetS 因素的健康成年人的 SLP。调整 AET 干预训练变量可能会增加 AET 对甘油三酯和 HDL-C 的影响。 PROSPERO 注册号 CRD42020151925。