Cancer prevalence is increasing in the last few decades with high mortality rates. It is a leading cause of death globally. Due to the rising prevalence of cancer and the emergence of conventional chemotherapy-related problems, the smart drug delivery system (SDDs) based on intrinsic, extrinsic stimuli-responsive nanocarriers has been widely studied. The current treatment available for cancer has drawbacks such as immune system weakness, irresponsive to treatment, non-specific target. The side effects of anticancer drugs can be reduced by encapsulation of the drug and targeted delivery at the cancer site. Stimuli responsive nanocarriers are effective for drug release at cancer sites to achieve target-specific delivery. These systems show superior ability for targeting cancerous cells without affecting healthy cells and offer the potential for advanced cancer therapies when compared to the conventional system. The present review involves recent advances in intrinsic, extrinsic, and dual-stimuli responsive nanomaterial systems for delivery of drug in cancer therapy.

在过去的几十年中，癌症患病率不断上升，死亡率很高。它是全球主要的死亡原因。由于癌症患病率的上升和常规化疗相关问题的出现，基于内在、外在刺激响应纳米载体的智能给药系统（SDDs）得到了广泛的研究。目前可用于癌症的治疗具有免疫系统弱、对治疗无反应、非特异性靶点等缺点。抗癌药物的副作用可以通过药物的封装和在癌症部位的靶向递送来减少。刺激响应纳米载体可有效地在癌症部位释放药物，以实现靶向特异性递送。与传统系统相比，这些系统显示出在不影响健康细胞的情况下靶向癌细胞的卓越能力，并为先进的癌症治疗提供了潜力。本综述涉及用于在癌症治疗中递送药物的内在、外在和双刺激响应纳米材料系统的最新进展。