This study evaluated such as exposure to ethinylestradiol during the prenatal (18th–22nd day) and pubertal (42nd–49th day) periods acts on the male ventral prostate and female prostate of 12-month old gerbils. We performed the analysis to serum hormone levels for estradiol and testosterone. The prostates were submitted to morphometric and immunohistochemical analyses. Exposure to ethinylestradiol during these developmental periods decreased the testosterone serum levels in males and increased the estradiol serum levels in females. Morphologically, prostate intraepithelial neoplasia and disorders in the arrangement of the fibrous components were observed in the prostate glands of both sexes of gerbil exposed to ethinylestradiol during development periods. In the male prostate, the ethinylestradiol promoted decreased in the frequency of positive epithelial cell for androgen receptor (AR) and increased the frequency of positive stromal cell for estrogen receptor α. However, in the female prostate, this synthetic estrogen caused AR upregulation and increased cell proliferation. This study shows that the exposure to ethinylestradiol during development phases alters the morphology and the hormonal signaling in the male and female prostates of old gerbils, confirming the action of ethinylestradiol as endocrine disruptor.

中文翻译：

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产前和青春期暴露于 17α-炔雌醇会导致老年沙鼠前列腺的形态学变化

本研究评估了诸如在产前（第 18-22 天）和青春期（第 42-49 天）期间暴露于炔雌醇对 12 个月大沙鼠的雄性腹侧前列腺和雌性前列腺的作用。我们对雌二醇和睾酮的血清激素水平进行了分析。对前列腺进行形态测量和免疫组织化学分析。在这些发育时期暴露于炔雌醇会降低男性血清睾酮水平并增加女性血清雌二醇水平。在形态学上，在发育期间暴露于炔雌醇的沙鼠两性前列腺中观察到前列腺上皮内瘤变和纤维成分排列紊乱。在男性前列腺中，炔雌醇促进雄激素受体（AR）阳性上皮细胞频率降低，增加雌激素受体α阳性基质细胞频率。然而，在女性前列腺中，这种合成雌激素导致 AR 上调和细胞增殖增加。这项研究表明，在发育阶段暴露于炔雌醇会改变老年沙鼠雄性和雌性前列腺的形态和激素信号，从而证实炔雌醇作为内分泌干扰物的作用。