Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis,Chemical Reviews

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Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-06-30 , DOI: 10.1021/acs.chemrev.1c00043
Mira Holzheimer ₁ , Jeffrey Buter ₁ , Adriaan J Minnaard ₁

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The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These cell wall components are often directly involved in host–pathogen interaction and recognition, intracellular survival, and virulence. For decades, these mycobacterial natural products have been of great interest for immunology and synthetic chemistry alike, due to their complex molecular structure and the biological functions arising from it. The synthesis of many of these constituents has been achieved and aided the elucidation of their function by utilizing the synthetic material to study Mtb immunology. This review summarizes the synthetic efforts of a quarter century of total synthesis and highlights how the synthesis layed the foundation for immunological studies as well as drove the field of organic synthesis and catalysis to efficiently access these complex natural products.

中文翻译：

结核分枝杆菌细胞壁成分的化学合成

引起结核病的病原体结核分枝杆菌( Mtb ) 具有异常厚的细胞包膜，富含Mtb特异性脂质、糖脂和聚糖。这些细胞壁成分通常直接参与宿主-病原体相互作用和识别、细胞内存活和毒力。几十年来，这些分枝杆菌天然产物因其复杂的分子结构和由此产生的生物学功能而引起了免疫学和合成化学等领域的极大兴趣。已经实现了许多这些成分的合成，并通过利用合成材料研究Mtb来帮助阐明它们的功能免疫学。这篇综述总结了四分之一世纪全合成的合成努力，并强调了合成如何为免疫学研究奠定基础，并推动有机合成和催化领域有效地获取这些复杂的天然产物。

更新日期：2021-08-11

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