Abstract

Methods of treating bone defects include autogenous bone and allogeneic bone transplantation, tissue engineering technology, gene therapy, growth factor and adjuvant therapy of physical therapy, etc. However, most treatment schemes have obvious disadvantages. The purpose of this paper is to study the application of graphene-based nanomaterials combined with early exercise rehabilitation training in the treatment of patients with infectious bone defects. The biomedical properties and biomedical applications of graphene are briefly introduced through literature research and investigation, and bone defect diseases and commonly used treatment methods are analyzed. Graphene is used in many biomedical fields, such as disease diagnosis, biosensing, antibacterial and antiviral materials, cancer targeting, photothermal therapy, drug delivery, cell electrical stimulation, tissue engineering, stem cell technology, DNA sequencing and fluorescent (FL) tracking molecular probes. The effects of graphene-based nanomaterials and rehabilitation exercise on the treatment of infectious bone defects were compared through controlled experiments. The results show that although the repair effect of graphene-based nano-materials is not as good as that of autogenous bone, the difference is not significant, and it is better than calcium phosphate cement. After rehabilitation exercise, the curative effect of graphene experimental group was improved. In the 12th week, the tensile strength reached 5.78 N, and the torsional strength reached 0.93 N m, which exceeded the group of autogenous bone without rehabilitation exercise. This paper discusses the strength-related repair effect, but the in vivo toxicity of graphene needs further study.

摘要

治疗骨缺损的方法包括自体骨和异体骨移植、组织工程技术、基因治疗、生长因子和物理治疗的辅助治疗等，但大多数治疗方案都存在明显的缺点。本文旨在研究石墨烯基纳米材料结合早期运动康复训练在治疗感染性骨缺损患者中的应用。通过文献研究和调查，简要介绍了石墨烯的生物医学特性和生物医学应用，分析了骨缺损疾病和常用的治疗方法。石墨烯用于许多生物医学领域，如疾病诊断、生物传感、抗菌和抗病毒材料、癌症靶向、光热疗法、药物输送、细胞电刺激、组织工程、干细胞技术、DNA 测序和荧光 (FL) 追踪分子探针。通过对照实验比较了基于石墨烯的纳米材料和康复运动治疗感染性骨缺损的效果。结果表明，石墨烯基纳米材料的修复效果虽然不如自体骨，但差异不显着，优于磷酸钙骨水泥。经过康复锻炼，石墨烯实验组的疗效有所提高。第12周时，抗拉强度达到5.78 N，扭转强度达到0.93 N·m，超过未进行康复锻炼的自体骨组。本文讨论了与强度相关的修复效果，