The solid-state cultivation of Acaulium sp. H-JQSF isolated from Armadillidium vulgare produces acautalides A–C (1–3) as skeletally unprecedented Diels–Alder adducts of a 14-membered macrodiolide to an octadeca-9,11,13-trienoic acid. The acautalide structures, along with the intramolecular transesterifications of 1-acylglycerols, were elucidated by mass spectrometry, nuclear magnetic resonance, chemical transformation, and single-crystal X-ray diffraction. Compounds 1–3 were found to be neuroprotective with antiparkinsonic potential in the 1-methyl-4-phenylpyridinium-challenged nematode model, with the magnitude impacted by the glycerol esterification.

中文翻译：

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Acautalides A-C，来自固态栽培的 Acaulium sp. 的神经保护 Diels-Alder 加合物。H-JQSF

Acaulium sp.的固态培养。H-JQSF分离自鼠妇产生acautalides A-C（1 - 3），为14元macrodiolide的骨骼前所未有狄尔斯-阿德耳加合物到十八碳9,11,13-三烯酸。通过质谱、核磁共振、化学转化和单晶 X 射线衍射阐明了 acautalide 结构以及 1-酰基甘油的分子内酯交换。化合物1 - 3被认为是神经保护与在1-甲基-4-苯基吡啶激发的线虫模型antiparkinsonic电位，与由甘油酯化影响的大小。