Targeted radionuclide therapy (TRNT) is characterized by systemic administration of radiolabelled drugs, targeting specific molecular alterations expressed on the tumour cells. Small molecules, labelled with β- or α- emitting radioisotopes, are used to deliver radiation directly to the tumour sites. Pretreatment imaging to visualize whole body biodistribution of the target, using the same drugs labelled with positron or γ-emitting radionuclides, completes the concept of theranostic. This review will briefly summarize the current clinical research findings and applications of TRNT in solid tumours, mostly focusing on neuroendocrine and prostate neoplasms.

中文翻译：

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靶向放射性核素治疗：实体瘤的新兴领域。

靶向放射性核素治疗（TRNT）的特点是全身施用放射性标记药物，针对肿瘤细胞上表达的特定分子改变。用 β 或 α 发射放射性同位素标记的小分子用于将辐射直接传递到肿瘤部位。使用标有正电子或 γ 发射放射性核素的相同药物，通过预处理成像来可视化目标的全身生物分布，从而完善了治疗诊断的概念。本文将简要总结目前TRNT在实体瘤方面的临床研究成果和应用，主要集中在神经内分泌肿瘤和前列腺肿瘤方面。