Mesenchymal stem cell-based tumor therapy is still limited due to the insufficient secretion of effectors and discrepancies between their in vitro and in vivo efficacy. We investigated whether genetically engineered adipose tissue-derived mesenchymal stem cells (ASCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) had inhibitory effects on H460 tumor growth both in vitro and in an H460 xenograft model.

中文翻译：

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TRAIL 过表达脂肪组织来源的间充质干细胞在 H460 异种移植模型中有效抑制肿瘤生长。

由于效应物分泌不足以及其体外和体内功效之间的差异，基于间充质干细胞的肿瘤治疗仍然受到限制。我们研究了过表达肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 的基因工程脂肪组织来源间充质干细胞 (ASC) 在体外和 H460 异种移植模型中是否对 H460 肿瘤生长具有抑制作用。