The common for the most part of tumor (GISTs) Gastrointestinal stromal tumor is known mesenchymal neoplasms of the tumor in gastrointestinal tract. Detection of serum miRNA 1, 15b, 21 adjustment mainly cardio marker enzymes and their mechanism of action and heart tissue, observed changes in LDH, CK-MB, AST, ALT, lipid peroxidation (LPO) and Troponin T estimations/biochemical changes observed in serum of experimental subjects (nicotine treated rats, 0.6 mg/kg, i.p.). In the present study, gastrointestinal stromal tumors of rats and the mitigation of cardiovascular complications was experimentally induced in rats by nicotine i.p. treatment of adult rats and maintained control rats. Confirm significantly decreased expression of miRNA-1 (nicotine induced gastrointestinal tumor rats), the levels of miRNA-15b expression is decrease in group II but miRNA-21 expression values are increased in experimental rats (group II) with control rats (group I). Body weight decreased significantly in group II nicotine induced rats and heart weight increased in group II but systolic blood pressure is decreased in experimental rats (group II) with control rats. Cardio marker enzyme levels were measured and increases LDH levels, slight raises CK-MB concentration range in group II. AST, ALT marker enzyme levels are higher in experimental rats with controls, troponin T values are clearly declare that some cardio complications in group II. Observed Ldh, Ck-Mb, Ast and Alt levels are decreased followed by antioxidant enzymes SOD, catalase but lipidperoxidation and protein carbonyls values are increased in nicotine induced rats and match up to normal rats. GST levels are increases significantly and Gpx, GRd and GSH levels are decreased in group II nicotine induced rats and corporately control group I. This study to investigates, for the first time, the effect of nicotine i.p., in adult rats (nicotine treated) and control rats. Reports of serum as well as heart tissue adjustment in molecular levels.

大部分肿瘤（GIST）常见的胃肠道间质瘤是胃肠道肿瘤的已知间叶性肿瘤。检测血清 miRNA 1、15b、21 调节主要是心脏标志酶及其作用机制和心脏组织，观察 LDH、CK-MB、AST、ALT、脂质过氧化 (LPO) 和肌钙蛋白 T 的变化估计/观察到的生化变化实验对象的血清（尼古丁处理的大鼠，0.6 mg/kg，ip）。在本研究中，通过对成年大鼠和维持对照大鼠进行尼古丁腹腔注射，实验诱导大鼠胃肠道间质瘤和心血管并发症的减轻。证实miRNA-1的表达显着降低（尼古丁诱导的胃肠道肿瘤大鼠），实验大鼠（Ⅱ组）和对照组（Ⅰ组）的miRNA-15b表达水平降低，但miRNA-21表达水平升高。II组尼古丁诱导的大鼠体重显着下降，II组心脏重量增加，但实验大鼠（II组）与对照大鼠的收缩压降低。测量心脏标记酶水平并增加 LDH 水平，轻微增加组 II 的 CK-MB 浓度范围。AST、ALT标记酶水平在对照组实验大鼠中较高，肌钙蛋白T值清楚地表明II组存在一些心脏并发症。观察到 Ldh、Ck-Mb、Ast 和 Alt 水平下降，其次是抗氧化酶 SOD，过氧化氢酶，但脂质过氧化和蛋白质羰基值在尼古丁诱导的大鼠中增加，与正常大鼠相匹配。GST 水平显着增加，Gpx、GRd 和 GSH 水平在组 II 尼古丁诱导大鼠和整体对照组 I 中降低。本研究首次调查了尼古丁 ip 对成年大鼠（尼古丁处理）和控制老鼠。血清和心脏组织在分子水平上的调整报告。