The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Here, we review the neuroanatomical and humoral basis of the cross-talk between the endocrine pancreas and autonomic and sensory neurons, including the extrapancreatic efferent and afferent pathways, intrapancreatic nervous division (neuro-insular complex), the enteropancreatic plexus, and the humoral crosstalk between the circumventricular organs and the pancreas. Identifying the neurocircuitry and neurochemistry of the neuro-insular network would provide clues to neuromodulation-based approaches for the prevention and treatment of diabetes and obesity.

中文翻译：

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胰脑串扰

在正常和挑战条件下葡萄糖稳态的神经调节涉及胰岛细胞功能的调节。在这里，我们回顾了内分泌胰腺与自主神经和感觉神经元之间串扰的神经解剖学和体液基础，包括胰外传出和传入通路、胰内神经分裂（神经岛复合体）、肠胰腺神经丛和体液串扰在室周器官和胰腺之间。识别神经岛网络的神经回路和神经化学将为基于神经调节的预防和治疗糖尿病和肥胖症的方法提供线索。